.The first written mention of Coltano is in a document dated 30 April 780 filed at the State Archives in Pisa. In the document, a Pisan nobleman asked the monks of San Savino Abbey for permission to go otter hunting near the church of San Quirico di Coltano. After changing hands many times, in 1562 pope Pius VI transferred the entire property of Coltano to San Savino Abbey, and more specifically to the military order of the Cavalieri di Santo Stefano.
Later, in 1586, Coltano passed to the Medici family and Prince Anthony expressed his intension to have a hunting and fishing residence built there. In April 1587, Grand Duke I started building the villa, designed by the famed architect Bernardo Buontalenti, which today stands in the middle of the old town.
The main activity of the Coltano estate was horse breeding, hunting and fishing. Most of the dry land was grassland used as pasture and farmland. The woods, mainly oak trees, elm oaks and British oaks, formed created a line around dry lands stopping the horses, which lived in the wild, from wandering from the pastures into the marshes.
The estate was greatly improved by the Lorena family, and particularly by the works carried out by Grand Duke Pietro Leopoldo I: from 1739 to 1788 several bridges were built and many trenches and channels were opened.
A pine tree-rowed lane (approximately 6 kilometres long) once known as Vione dei Pini (today called Via della Sofina) was built then.
The lane went from the Coltano villa to San Piero a Grado.After the unification of Italy, estate become property of the crown under Vittorio Emanuele II in 1860 and a royal hunting estate for the enjoyment of the king and the royal family.